2014年2月開院、奈良市法蓮町の内科。やまがた内科医院です。

TEL. 0742-20-6220
FAX. 0742-20-6221

〒630-8113 奈良県奈良市法蓮町 1095

院長経歴及び業績詳細

院長経歴詳細

大学卒業後、京都府立医科大学第二内科へ入局。
循環器、呼吸器、血液疾患を中心に研鑽。 京都第二日赤病院救命救急センターや京都府立与謝の海病院で救急医療についても研修を積んだ。

卒後3年目から、社会保険神戸中央病院、内科へ赴任。内科医員として広く一般内科診療を行いながら、胃カメラ、腹部超音波検査、心臓超音波検査、心臓血管カテーテル検査やペースメーカー植え込みといった専門領域の手技についても経験を重ねた。 透析について学会の研修会を受講し修了。 広く実地診療経験を積んだ。

卒後5年目から、京都府立医科大学大学院へ進む。大学院で血液内科領域の研究(悪性疾患に対する末梢血幹細胞移植に関する研究)、
診療を行いながら、大学病院で、胃透視、腹部超音波検査を担当。研修医の指導に当たった。 市中病院では、胃カメラを担当し一般内科診療を行った。

卒後9年目(大学院修了後)から、公立南丹病院へ赴任。 1年目は、一般内科診療、消化器領域を中心とした検査(胃カメラ、腹部超音波検査等)を担当した。 在宅診療も担当し、軽乗用車で近隣の在宅診療にまわり、在宅高カロリー輸液、在宅化学療法やおみとりも含む診療経験を積んだ。 2年目になり、血液内科が創設され、初代医長を担当し科の診療の充実を図った。 在宅診療は継続して行い研鑽、診療内容の充実に努めた。

卒後12年目から、アメリカ、テネシー州、ナッシュビルにある、バンダービルト・イングラム癌センター(バンダービルト大学)へ留学。 悪性疾患の遺伝子発現や癌の免疫治療に関連した研究を行った。

卒後15年目から、国立国際医療センター(現;国立国際医療研究センター)へ赴任。 血液内科の診療、研究を行った。 骨髄バンク連絡責任医師、臍帯血バンク連絡責任者、日本成人白血病治療共同研究グループ(JALSG)運営委員を務め、血液内科病棟医長。

卒後
18年目から、高の原中央病院、血液内科へ赴任。 血液疾患診療にあたり、貧血や、白血病、悪性リンパ腫、骨髄腫をはじめとした血液悪性腫瘍の診療を中心に担当した。

院長業績詳細
論文発表(英文)

Original reports:

  1. Murata M, Nishida T, Taniguchi S, Ohashi K, Ogawa H, Fukuda T, Mori T, Kobayashi H, Nakaseko C, Yamagata N, Morishima Y, Nagamura-Inoue T, Sakamaki H, Atsuta Y, Suzuki R, Naoe T. Allogeneic transplantation for primary myelofibrosis with BM, peripheral blood or umbilical cord blood: an analysis of the JSHCT. Bone Marrow Transplant. 2014 Mar;49(3):355-60. doi: 10.1038/bmt.2013.180. Epub 2013 Nov 25. PMID: 24270391
  2. Miwa A, Sekiguchi N, Tanimura A, Homma C, Shikai T, Takezako Y, Yamagata N, Takezako N. Ranimustine, ifosfamide, procarbazine, dexamethasone, and etoposide therapy for central nervous system recurrence of diffuse large B-cell lymphoma in patients with poor performance status: a pilot study. Leuk Lymphoma. 2011 Oct;52(10):1898-903. Epub 2011 Jun 8. PubMed PMID: 21649542.
  3. Yamagata N, Fujio J, Hirai R, Matsumaru M, Tanimura S, Inokuchi C, Shikai T, Takezako N, Nasu M, Sakata Y, Sata N, Nagai H, Saito K, Miwa A. Marked hepatomegaly due to AA type amyloidosis in a case with Castleman’s disease. Int J Hematol. 2006 Jul;84(1):70-3. PubMed PMID: 16867906.
  4. Kagawa N, Senbonmatsu TA, Satoh K, Ichihara K, Yamagata N, Hatano O, Saito T, Nguyen VQ, Waterman MR, Price E Jr, Atkinson JB, Inagami T. Tetracycline protects myocardium against ischemic injury. Front Biosci. 2005 Jan 1;10:608-19. Print 2005 Jan 1. PubMed PMID: 15569603.
  5. Takezako N, Miwa A, Tanimura A, Inokuchi C, Shikai T, Yamagata N, Togawa A. Intensified conditioning regimen has only limited value for patients with progressive multiple myeloma. Int J Hematol. 2003 Oct;78(3):270-1. PubMed PMID: 14604290.
  6. Yamagata N, Shyr Y, Yanagisawa K, Edgerton M, Dang TP, Gonzalez A, Nadaf S, Larsen P, Roberts JR, Nesbitt JC, Jensen R, Levy S, Moore JH, Minna JD, Carbone DP. A training-testing approach to the molecular classification of resected non-small cell lung cancer. Clin Cancer Res. 2003 Oct 15;9(13):4695-704. PubMed PMID: 14581339.
  7. Yang L, Yamagata N, Yadav R, Brandon S, Courtney RL, Morrow JD, Shyr Y, Boothby M, Joyce S, Carbone DP, Breyer RM. Cancer-associated immunodeficiency and dendritic cell abnormalities mediated by the prostaglandin EP2 receptor. J Clin Invest. 2003 Mar;111(5):727-35. PubMed PMID: 12618527; PubMed Central PMCID: PMC151895.
  8. Adachi Y, Lee CT, Coffee K, Yamagata N, Ohm JE, Park KH, Dikov MM, Nadaf SR, Arteaga CL, Carbone DP. Effects of genetic blockade of the insulin-like growth factor receptor in human colon cancer cell lines. Gastroenterology. 2002 Oct;123(4):1191-204. PubMed PMID: 12360481.
  9. Asai K, Kitaura J, Kawakami Y, Yamagata N, Tsai M, Carbone DP, Liu FT, Galli SJ, Kawakami T. Regulation of mast cell survival by IgE. Immunity. 2001 Jun;14(6):791-800. PubMed PMID: 11420048.
  10. Inaba T, Shimazaki C, Sumikuma T, Okano A, Hatsuse M, Okamoto A, Takahashi R, Ashihara E, Hibi S, Sudo Y, Yamagata N, Murakami S, Rin K, Fujita N, Yoshimura M, Nakagawa M. Expression of T-cell-associated antigens in B-cell non-Hodgkin’s lymphoma. Br J Haematol. 2000 Jun;109(3):592-9. PubMed PMID: 10886209.
  11. Kikuta T, Shimazaki C, Ashihara E, Sudo Y, Hirai H, Sumikuma T, Yamagata N, Inaba T, Fujita N, Kina T, Nakagawa M. Mobilization of hematopoietic primitive and committed progenitor cells into blood in mice by anti-vascular adhesion molecule-1 antibody alone or in combination with granulocyte colony-stimulating factor. Exp Hematol. 2000 Mar;28(3):311-7. PubMed PMID: 10720696.
  12. Takenaka H, Kishimoto S, Ichikawa R, Shibagaki R, Kubota Y, Yamagata N, Gotoh H, Fujita N, Yasuno H. Virus-associated haemophagocytic syndrome caused by rubella in an adult. Br J Dermatol. 1998 Nov;139(5):877-80. PubMed PMID: 9892958.
  13. Feng R, Shimazaki C, Inaba T, Takahashi R, Hirai H, Kikuta T, Sumikuma T, Yamagata N, Ashihara E, Fujita N, Nakagawa M. CD34+/CD41a+ cells best predict platelet recovery after autologous peripheral blood stem cell transplantation. Bone Marrow Transplant. 1998 Jun;21(12):1217-22. PubMed PMID: 9674855.
  14. Shiina T, Tamiya G, Oka A, Yamagata T, Yamagata N, Kikkawa E, Goto K, Mizuki N, Watanabe K, Fukuzumi Y, Taguchi S, Sugawara C, Ono A, Chen L, Yamazaki M, Tashiro H, Ando A, Ikemura T, Kimura M, Inoko H. Nucleotide sequencing analysis of the 146-kilobase segment around the IkBL and MICA genes at the centromeric end of the HLA class I region. Genomics. 1998 Feb 1;47(3):372-82. PubMed PMID:9480751.
  15. Ashihara E, Shimazaki C, Sudo Y, Kikuta T, Hirai H, Sumikuma T, Yamagata N, Goto H, Inaba T, Fujita N, Nakagawa M. FLT-3 ligand mobilizes hematopoietic primitive and committed progenitor cells into blood in mice. Eur J Haematol. 1998 Feb;60(2):86-92. PubMed PMID: 9508348.
  16. Inaba T, Shimazaki C, Sumikuma T, Takahashi R, Hirai H, Kikuta T, Sudo Y, Yamagata N, Ashihara E, Goto H, Fujita N, Yoshimura M, Nakagawa M. Flow cytometric analysis of Thy-1 expression in CD34-positive acute leukemia. Int J Hematol. 1997 Oct;66(3):315-23. PubMed PMID: 9401277.
  17. Yamagata N, Shimazaki C, Kikuta T, Hirai H, Sumikuma T, Sudo Y, Ashihara E, Goto H, Inaba T, Fujita N, Nakagawa M. A translocation between 3q21 and 12q24 in a patient with minimally differentiated acute myeloid leukemia (AML-M0). Cancer Genet Cytogenet. 1997 Sep;97(2):90-3. PubMed PMID: 9283587.
  18. Hirai H, Shimazaki C, Yamagata N, Goto H, Inaba T, Kikuta T, Sumikuma T, Sudo Y, Ashihara E, Fujita N, Hibi S, Imashuku S, Ito E, Nakagawa M. Effects of thrombopoietin (c-mpl ligand) on growth of blast cells from patients with transient abnormal myelopoiesis and acute myeloblastic leukemia. Eur J Haematol. 1997 Jul;59(1):38-46. PubMed PMID: 9260579.
  19. Shimazaki C, Goto H, Araki S, Tatsumi T, Takahashi R, Hirai H, Kikuta T, Yamagata N, Ashihara E, Inaba T, Fujita N, Suzuki R, Nakagawa M. Overexpression of PRAD1/cyclin D1 in plasma cell leukemia with t(11;14)(q13;q32). Int J Hematol. 1997 Jul;66(1):111-5. PubMed PMID: 9220667.
  20. Onishi R, Tanaka K, Shimazaki C, Yamagata N, Konaka Y, Namiuchi S, Kamada N. Sequential interphase FISH analysis of m-BCR/ABL chimeric gene-positive cells in Ph-positive acute myeloid leukemia. Leuk Lymphoma. 1997 Jun;26(1-2):185-91. PubMed PMID: 9250805.
  21. Sudo Y, Shimazaki C, Ashihara E, Kikuta T, Hirai H, Sumikuma T, Yamagata N, Goto H, Inaba T, Fujita N, Nakagawa M. Synergistic effect of FLT-3 ligand on the granulocyte colony-stimulating factor-induced mobilization of hematopoietic stem cells and progenitor cells into blood in mice. Blood. 1997 May 1;89(9):3186-91. PubMed PMID: 9129021.
  22. Shimazaki C, Inaba T, Uchiyama H, Sumikuma T, Kikuta T, Hirai H, Sudo Y, Yamagata N, Ashihara E, Goto H, Murakami S, Haruyama H, Fujita N, Nakagawa M. Serum thrombopoietin levels in patients undergoing autologous peripheral blood stem cell transplantation. Bone Marrow Transplant. 1997 Apr;19(8):771-5. PubMed PMID: 9134167.
  23. Tatsumi T, Shimazaki C, Araki SI, Sudo Y, Yamagata N, Ashihara E, Goto H, Inaba T, Fujita N, Nakagawa M, Misawa SI, Imashuku S. Philadelphia chromosome-positive acute lymphoblastic leukemia after therapy for Langerhans cell histiocytosis. Am J Hematol. 1997 Jan;54(1):88. PubMed PMID: 8980271.
  24. Tatsumi T, Shimazaki C, Goto H, Araki S, Sudo Y, Yamagata N, Ashihara E, Inaba T, Fujita N, Nakagawa M. Expression of adhesion molecules on myeloma cells. Jpn J Cancer Res. 1996 Aug;87(8):837-42. PubMed PMID: 8797890.
  25. Suzuki S, Osaka Y, Nakai I, Yasumura T, Omori Y, Yamagata N, Shimazaki C, Oka T. Pure red cell aplasia induced by FK506. Transplantation. 1996 Mar 15;61(5):831-2. PubMed PMID: 8607191.
  26. Inaba T, Shimazaki C, Hirai H, Kikuta T, Sumikuma T, Sudo Y, Yamagata N, Ashihara E, Goto H, Fujita N, Nakagawa M. Familial polycythemia vera in father and daughter. Am J Hematol. 1996 Feb;51(2):172. PubMed PMID: 8579063.
  27. Inaba T, Shimazaki C, Yoneyama S, Hirai H, Kikuta T, Sumikuma T, Sudo Y, Yamagata N, Ashihara E, Goto H, Fujita N, Nakagawa M. t(7;11) and trilineage myelodysplasia in acute myelomonocytic leukemia. Cancer Genet Cytogenet. 1996 Jan;86(1):72-5. PubMed PMID: 8616792.
  28. Shimazaki C, Uchiyama H, Fujita N, Araki S, Sudo Y, Yamagata N, Ashihara E, Goto H, Inaba T, Haruyama H, et al. Serum levels of endogenous and exogenous granulocyte colony-stimulating factor after autologous blood stem cell transplantation. Exp Hematol. 1995 Dec;23(14):1497-502. PubMed PMID: 8542937.
  29. Shinno K, Tsuboyama K, Mine H, Maruya E, Nita H, Masuda H, Yamagata N, Tsuji H, Nakagawa M, Saji H. Nucleotide sequence of a new DRB1*15 variant, 1505, in a Japanese family. Tissue Antigens. 1995 Nov;46(5):411-3. PubMed PMID: 8838355.
  30. Shimazaki C, Yamagata N, Tatsumi T, Hirata T, Oku N, Ashihara E, Goto H, Inaba T, Fujita N, Haruyama H, et al. Mobilization of peripheral blood progenitor cells by high-dose Ara C, VP-16 and recombinant human granulocyte colony-stimulating factor: factors affecting progenitor cell yields. Bone Marrow Transplant. 1995 May;15(5):763-7. PubMed PMID: 7545490.
  31. Goto H, Shimazaki C, Tatsumi T, Yamagata N, Fujita N, Tsuchiya M, Koishihara Y, Ohsugi Y, Nakagawa M. Establishment of a novel myeloma cell line KPMM2 carrying t(3;14)(q21;q32), which proliferates specifically in response to interleukin-6 through an autocrine mechanism. Leukemia. 1995 Apr;9(4):711-8. PubMed PMID: 7723407.
  32. Uchiyama H, Shimazaki C, Fujita N, Tatsumi T, Yamagata N, Hirata T, Ashihara E, Oku N, Goto H, Inaba T, et al. Kinetics of serum cytokines in adults undergoing peripheral blood progenitor cell transplantation. Br J Haematol. 1994 Nov;88(3):639-42. PubMed PMID: 7819082.
  33. Goto H, Shimazaki C, Tatsumi T, Yamagata N, Inaba T, Fujita N, Moriguchi T, Yamamoto K, Seto M, Ueda R, et al. Acute myelomonocytic leukemia after treatment with chronic oral etoposide: are MLL and LTG9 genes targets for etoposide? Int J Hematol. 1994 Aug;60(2):145-9. PubMed PMID: 7948964.
  34. Goto H, Shimazaki C, Tatsumi T, Yamagata N, Hirata T, Ashihara E, Oku N, Inaba T, Fujita N, Koishihara Y, et al. Mouse anti-human interleukin-6 receptor monoclonal antibody inhibits proliferation of fresh human myeloma cells in vitro. Jpn J Cancer Res. 1994 Sep;85(9):958-65. PubMed PMID: 7961126.
  35. Ashihara E, Shimazaki C, Yamagata N, Hirata T, Okawa K, Oku N, Goto H, Inaba T, Fujita N, Nakagawa M. Reconstitution of lymphocyte subsets after peripheral blood stem cell transplantation: two-color flow cytometric analysis. Bone Marrow Transplant. 1994 Apr;13(4):377-81. PubMed PMID: 7912603.
  36. Yamagata N, Shimazaki C, Goto H, Hirata T, Ashihara E, Oku N, Inaba T, Fujita N, Nakagawa M. IgE plasma cell leukemia successfully treated with combination VAD(vincristine, doxorubicin, dexamethasone) and MP (melphalan, prednisolone) followed by interferon-alpha. Am J Hematol. 1994 Mar;45(3):262-4. PubMed PMID:8296801.
  37. Morimoto S, Shimazaki C, Goto H, Hirata Y, Tasumi T, Yamagata N, Hirata T, Ashihara E, Inaba T, Fujita N, et al. Trichosporon cutaneum fungemia in patients with acute myeloblastic leukemia and measurement of serum D-arabinitol, Candida antigen (CAND-TEC), and beta-D-glucan. Ann Hematol. 1994 Mar;68(3):159-61. PubMedPMID: 8167183.
  38. Shimazaki C, Oku N, Uchiyama H, Yamagata N, Tatsumi T, Hirata T, Ashihara E, Okawa K, Goto H, Inaba T, et al. Effect of granulocyte colony-stimulating factor on hematopoietic recovery after peripheral blood progenitor cell transplantation. Bone Marrow Transplant. 1994 Mar;13(3):271-5. PubMed PMID: 7515300.
  39. Inaba T, Shimazaki C, Tatsumi T, Yamagata N, Hirata T, Goto H, Fujita N, Nakagawa M. Expression of differentiation-associated antigens and adhesion molecules on CD34-positive cells harvested from peripheral blood and bone marrow. Prog Clin Biol Res. 1994;389:331-7. PubMed PMID: 7535439.

論文発表(和文) (筆頭論文のみ)

1.山形 昇、中村隆志、東 秋弘、成原理佳、杉原洋樹、河野義雄、勝目 紘、中川雅夫、経胸壁法による左冠状動脈中隔枝血流評価、日本超音波学会雑誌、11,239240,1991

2.山形 昇、中村隆志、成原理佳、東 秋弘、松室明義、杉原洋樹、河野義 雄、勝目 紘、中川雅夫、国重 宏、経胸壁法による左冠状動脈中隔枝血流評価、呼吸と循環、41,165170,1993

3.山形 昇、西田康一、深堀 隆、松葉光也、溝渕一哉、小笠原由子、橋倉博樹、若槻祐子、中村充男、真崎 亮、肉腫様変化を伴った肝細胞癌の一例、社会保険神戸中央病院雑誌、6,1418,1995

4.山形 昇、島崎千尋、辰巳哲也、平田俊幸、芦原英司、後藤秀夫、稲葉 亨、中川雅夫、藤田直久、末梢血幹細胞中CD34陽性細胞分離に関する基礎的検討、日本輸血学会雑誌、41,7172、1995

5.山形 昇、末梢血CD34陽性幹細胞分離法の検討とその臨床応用に関する研究、京都府立医科大学雑誌、107,4359,1998

. 山形 昇、多発性骨髄腫の多様性 ― 遺伝子からみた多様性、カレントテラピー、28(3), 26-31、2010